There was a question about alcohol earlier, I did not find this evening on a quick rescan looking to quote somebody.
The question, more or less, was "How much alcohol is safe to drink?"
The answer is "it depends" and even with that the answer is a moving target. I spent a little time today looking for a recent meta-analysis, where someone reads a bunch of scholarly articles on a particular subject, and then writes a scientific paper on the aggregate data set. I didn't find one in the time I had.
Briefly, ethanol, beverage alcohol, is cytotoxic. Ethanol will kill cells. Within the hospital we can do this intentionally, I did find a short article today about using ultrasound guidance to inject cystic thyroid lesions with absolute alcohol (medical grade, 200 proof hooch) for definitive treatment. We can use it for pain control in cases of chronic pancreatitis by killing off some of the nerve cells that connect from the pancreas to the pain centers in the brain.
In some drinkers, alcohol kills brain cells. In others, we sometimes see peripheral alcohol induced neuropathy like diabetics can get from diabetes. In some folks ethanol kills heart muscle cells. Liver damage you have probably heard of. I know there is a strong correlation between high alcohol consumption for both strokes and heart attack. There may be a causal link between alcohol and CVD - I went to school 25+ years ago and simply cannot keep up with everything.
I have noticed over the decades the amount of drinking that is considered safe keeps getting lower and lower.
The studies I have read are fairly uniform, when looking at moderate to large sample sizes, the more you drink, and the more often you drink whatever amount, the higher your risk of complications from drinking.
So like much in life, dose dependent.
But there is another angle here. The good Lord put yeast cells right on the skin of the grape. You simply could not make grape juice (and not end up with wine) from prehistory up to Mr. Welch figuring out how to pasteurize grape juice in 1869. It is speculated the Wesleyan Methodists were steeping raisins in hot water so they could give valid Holy Communion to recovering alcoholics until Mr. Welch ( a staunch Wesleyan and teetotaler) had his breakthrough.
In my bedside experience, I find folks that admit to six drinks a day and up are already having deleterious health effects in their early 50s and are clearly on the road to ruin, no matter how good their genes are. Their hair doesn't look right, their skin doesn't look right, some of them are getting a red nose already, as a group they are taking damage points faster than they can self repair, and they are not in hospital for a nap on the way to the golf course. This isn't a process that can turn around in one week, and for many folks the damage is visible earlier.
I find folks I suspect are drinking six drinks daily, even though they admit to 2-4 drinks daily, those ones I can spot definitively in their mid 50s.
On the other hand a couple Guinness in the evening dramatically lowers my risk of killing stupid people. So do I want to live to be 80 in a penitentiary somewhere with no Guinness for 20 years, or kick off in my mid 70s, at home, with Guinness in the fridge for tomorrow?
There are a fair number of pages under this umbrella at cdc.gov. I am confident if you look again in ten years whatever counts as moderate drinking in 2033 will be lower amounts than what you will read today.
https://www.cdc.gov/alcohol/index.htm