One 300mg tablet a week is Malaria Prophylaxis, and the treatment dose was 500-600 a day. Big difference. You can use 100mg-200mg a day with Doxy for the same results. We had way less side effects with the doxy on deployment and most were switched to that within 2 months. Our pilots always used doxy, they would have been grounded for 48hrs after every dose due to the side effects.
If anyone wants to look at what’s really being looked at do a search on COVID-19 and Cytokine Storm Syndrome. I had one of these pts Last night. It was unreal, even the ER doc said he’s never seen anything like it ever before. There is a lot of research being done to isolate which of the cytokines are responsible for the storm to develop therapies that will individually block them, right now high dose steroids are the best option. With these very sick pts, thank god there are very few, the pneumonia progresses from a fairly clear chest X-ray to an almost opaque chest x ray in a couple of hours. They are fairly confident this is from the autoimmune response from a cytokine storm. The pts burn through drugs at an unbelievably high rate, paralytics and Sedation drugs are effective for less than than half the normal duration.
The treatment, as far as coming up with supportive care, lays with immunologists and rheumatologists as this is their area of specialty. What I have learned from a couple long distance transfers, each over 2 hours, was they present like septic pts and they are very hard to manage. BPs all over the spectrum and normal treatments do not become to stabilize them. Last nights was by far one of the sickest patients I have seen in 25 years. My recommendation Now is to utilize Mobile Intensive Care units due to the availability an RN, RT and better medications than we utilize. It’s difficult to manage airway demands, meds, etc with one set of hands as fast as the pts condition changes. I didn’t know which way was up when we got to the receiving hospital.
While I will say my eyes are opened now to how sick these pts can actually get, don’t jump my ass because my feelings on getting back to normal have not changed lol. Took 6 weeks for our hospital to see one of these patients.